CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Telomerase promotes Hepatocarcinogenesis in the context of p53- and Telomerase-Dysfunction by limiting Chromosomal Instability
DOI 10.1055/s-2006-931688
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Lechel, H Holstege, Y Begus, A Schienke, K Kamino, U Lehmann, J Buer, J Buer, MP Manns, S Kubicka, P Schirrmacher, J Jonkers, P Schirrmacher, KL Rudolph
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Telomere shortening and p53 deletion cooperatively induce chromosomal instability and cancer initiation at the crisis stage, but the role of telomerase in this scenario remains to be defined. We generated a humanized mouse model in which hepatocellular cancer (HCC) was induced by chronic liver damage, telomere shortening, and targeted p53 deletion in mouse liver. In this model HCC developed at an age of 12–15 months…
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Zitierempfehlung
A Lechel, H Holstege, Y Begus, A Schienke, K Kamino, U Lehmann, J Buer, J Buer, MP Manns, S Kubicka, P Schirrmacher, J Jonkers, P Schirrmacher, KL Rudolph (2006) Telomerase promotes Hepatocarcinogenesis in the context of p53- and Telomerase-Dysfunction by limiting Chromosomal Instability. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2006-931688
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