CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Role of hypoxia-inducible transcription factors (HIFs) in oxygen-dependent modulation of IGF binding protein–1 biosynthesis in primary rat hepatocytes
DOI 10.1055/s-2006-931698
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Nachweis in CareLit
Autor:innenJG Scharf, TG Unterman, G Ramadori, T Kietzmann
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Higher levels of IGFBP–1 mRNA are expressed in the less aerobic perivenous zone of the liver. Since gradients in oxygen tension (pO2) may contribute to zonated gene expression, the influence of arterial and venous pO2 on IGFBP–1 biosynthesis was studied in primary cultures of rat hepatocytes. Maximal IGFBP–1 mRNA and protein levels were observed under venous pO2 whereas less than 30% of maximal levels were observed…
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Zitierempfehlung
JG Scharf, TG Unterman, G Ramadori, T Kietzmann (2006) Role of hypoxia-inducible transcription factors (HIFs) in oxygen-dependent modulation of IGF binding protein–1 biosynthesis in primary rat hepatocytes. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2006-931698
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