CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Multigenotype HCV-NS3 recombinant vaccinia viruses as a model for evaluating cross-genotype immunity induced by HCV vaccines in the mouse
DOI 10.1055/s-2006-931742
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Autor:innenC Eisenbach, A Freyse, CM Lupu, K Weigand, E Ernst, B Hoyler, W Stremmel, JJ Bugert, J Encke
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Surrogate infections with HCV-recombinant vaccinia virus (HCV-rVV) are a standard method to test the efficacy of hepatitis C virus (HCV) vaccine candidates in the mouse model. We established a panel of 16 HCV-rVV expressing the nonstructural protein 3 (NS3) of HCV genotypes 1a, 1b, 2, 3 and 4. Mice immunized with recombinant NS3 protein derived from HCV genotype 1b were challenged with the rVV. rVV-titers decreased…
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Zitierempfehlung
C Eisenbach, A Freyse, CM Lupu, K Weigand, E Ernst, B Hoyler, W Stremmel, JJ Bugert, J Encke (2006) Multigenotype HCV-NS3 recombinant vaccinia viruses as a model for evaluating cross-genotype immunity induced by HCV vaccines in the mouse. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2006-931742
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