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High frequency of anti-PDC-E1a/E1b antibodies in sera from primary biliary cirrhosis patients: affinity purification of the mitochondrial M4 antigen predominantly enriches pyruvate dehydrogenase complex E1achains

CP Berg, GM Stein, R Klein, M Pascu, T Berg, W Kammer, M Priemer, A Nordheim, K Schulze-Osthoff, M Gregor, S Wesselborg, PA Berg · Zeitschrift für Gastroenterologie · Ausgabe 01/2006

DOI 10.1055/s-2006-931776

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Autor:innenCP Berg, GM Stein, R Klein, M Pascu, T Berg, W Kammer, M Priemer, A Nordheim, K Schulze-Osthoff, M Gregor, S Wesselborg, PA Berg
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2006
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Objective: Sera from patients with primary biliary cirrhosis (PBC) contain antibodies against intracellular antigens such as denatured epitopes of the pyruvate dehydrogenase complex (PDC) derived from bovine heart mitochondria (M2). In addition, native proteins were detected within the sucrose gradient fractions derived from rat liver mitochondria (M4) only by the complement fixation test but not in Western Blot ana…

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CP Berg, GM Stein, R Klein, M Pascu, T Berg, W Kammer, M Priemer, A Nordheim, K Schulze-Osthoff, M Gregor, S Wesselborg, PA Berg (2006) High frequency of anti-PDC-E1a/E1b antibodies in sera from primary biliary cirrhosis patients: affinity purification of the mitochondrial M4 antigen predominantly enriches pyruvate dehydrogenase complex E1achains. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2006-931776

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