CareLit · DOI-Nachweis · Pneumologie
Prevalence of pneumococci with single mutations within fluoroquinolone resistance genes
DOI 10.1055/s-2006-932716
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Autor:innenC Duesberg, T Nguyen, T Welte, M Pletz
ZeitschriftPneumologie
Ausgabe02/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Discordant antibiotic treatment of fluoroquinolone (FQ) resistant pneumococci causes treatment failure in patients with pneumonia. Resistance to FQs occurs in a stepwise fashion by the acquisition of mutations within the FQ binding sites (QRDR) in the target enzymes DNA gyrase (gyrA and gyrB), and topoisomerase IV (parC and parE). Whereas complete resistance to FQs mainly occurs if mutations in both targ…
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Zitierempfehlung
C Duesberg, T Nguyen, T Welte, M Pletz (2006) Prevalence of pneumococci with single mutations within fluoroquinolone resistance genes. Pneumologie (02). https://doi.org/10.1055/s-2006-932716
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