CareLit · DOI-Nachweis · Pneumologie
Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration
DOI 10.1055/s-2006-933800
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Pullamsetti, S Krick, A Ghofrani, C Schudt, N Weissmann, W Seeger, F Grimminger, R Schermuly
ZeitschriftPneumologie
Ausgabe04/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The aim of the study was to assess the chronic effects of combined phosphodiesterase 3/4 inhibitor tolafentrine, administered by inhalation, during monocrotaline-induced pulmonary arterial hypertension (MCT-PAH) in rats. Monocrotaline injection provoked severe PAH, cardiac output depression and right heart hypertrophy. The media thickness of the pulmonary arteries and the proportion of muscularization of resistance…
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Zitierempfehlung
S Pullamsetti, S Krick, A Ghofrani, C Schudt, N Weissmann, W Seeger, F Grimminger, R Schermuly (2006) Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration. Pneumologie (04). https://doi.org/10.1055/s-2006-933800
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