CareLit · DOI-Nachweis · Klinische Neurophysiologie
Dantrolene protects motoneurons in culture against AMPA receptor mediated excitotoxicity
DOI 10.1055/s-2006-939158
Bibliografische Angaben
Nachweis in CareLit
Autor:innenK Haastert, K Jahn, R Dengler, C Grothe, J Bufler, J Grosskreutz
ZeitschriftKlinische Neurophysiologie
Ausgabe03/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Chronic excitotoxicity induced by overstimulation of calcium permeable AMPA receptors (AMPAR) was shown to be a key factor in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). The presence of AMPAR, however, is also necessary for neuronal development. AMPAR may exert such bimodal influence on neuronal survival by altering intracellular calcium homeostasis through control of calcium induced calcium release fro…
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Zitierempfehlung
K Haastert, K Jahn, R Dengler, C Grothe, J Bufler, J Grosskreutz (2006) Dantrolene protects motoneurons in culture against AMPA receptor mediated excitotoxicity. Klinische Neurophysiologie (03). https://doi.org/10.1055/s-2006-939158
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