CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
A balanced activation of regulatory subunits of phosphoinositide 3-kinase defines proliferation and survival in pancreatic beta-cells
DOI 10.1055/s-2006-943808
Bibliografische Angaben
Nachweis in CareLit
Autor:innenD Hörsch, P Niebel, J Schrader
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe06/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Protein kinase B (PKB; also known as Akt) is pivotal for beta-cell growth and survival. The main activator of PKB is the lipid kinase phosphinositide 3-kinase (PI3K), which is active as a heterodimer of regulatory and catalytic subunits and may be inhibited by an excess of free regulatory subunits. Alternative splicing of the Pik3r1 gene yields the three PI3K regulatory isoforms p85a, p55a and p50a. Since little is…
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Zitierempfehlung
D Hörsch, P Niebel, J Schrader (2006) A balanced activation of regulatory subunits of phosphoinositide 3-kinase defines proliferation and survival in pancreatic beta-cells. Diabetologie und Stoffwechsel (06). https://doi.org/10.1055/s-2006-943808
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