CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Overexpression of Ngn3 and Pdx-1 in human bone marrow derived mesenchymal (hMSC-TERT) stem cells triggers endocrine pancreatic gene expression
DOI 10.1055/s-2006-943928
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Nachweis in CareLit
Autor:innenC Limbert, G Päth, X Niu, V Rothhammer, M Kassem, J Seufert
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe06/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Adult stem cells are investigated as an alternative source for beta-cell replacement therapy. So far, no consistent differentiation capacity for insulin producing cells has been shown in human bone marrow derived mesenchymal stem cells (MSC). Neurogenin 3 (Ngn3) and Pdx-1 are key transcription factors for the specification of endocrine pancreatic cell lineage and/or insulin expression. Here we investigated the abili…
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Zitierempfehlung
C Limbert, G Päth, X Niu, V Rothhammer, M Kassem, J Seufert (2006) Overexpression of Ngn3 and Pdx-1 in human bone marrow derived mesenchymal (hMSC-TERT) stem cells triggers endocrine pancreatic gene expression. Diabetologie und Stoffwechsel (06). https://doi.org/10.1055/s-2006-943928
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