CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Mechanism of MgATP-induced SUR1/Kir6.2 activation
DOI 10.1055/s-2006-943966
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Nachweis in CareLit
Autor:innenM Schwanstecher, M Schulz, M Beyer, C Schwanstecher
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe06/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Objective: SUR1/Kir6.2 channels are of key importance in insulin release. MgATP critically controls these channels by interaction with SUR1. Aims: In this study we focussed on further elucidating the molecular basis of this interaction. Methods: For this purpose we constructed a series of SUR1 mutations. These mutants were transiently coexpressed in COS-cells and effects of nucleotides on channel activity were teste…
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Zitierempfehlung
M Schwanstecher, M Schulz, M Beyer, C Schwanstecher (2006) Mechanism of MgATP-induced SUR1/Kir6.2 activation. Diabetologie und Stoffwechsel (06). https://doi.org/10.1055/s-2006-943966
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