CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
IL-23 cross-regulates IL-12 production in T cell dependent experimental colitis
DOI 10.1055/s-2006-950635
Bibliografische Angaben
Nachweis in CareLit
Autor:innenC Becker, H Dornhoff, C Neufert, M Fantini, S Wirtz, S Hübner, A Nikolaev, HA Lehr, AJ Murphy, DM Valenzuela, GD Yancopoulus, PR Galle, M Karow, MF Neurath
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
IL-12 is a key regulatory cytokine in cell-mediated immunity and induces the differentiation of naïve T cells towards a TH1 phenotype. The pathogenic activity of IL-12 has been demonstrated in various TH1-mediated experimental models of autoimmune diseases including inflammatory bowel disease (IBD). Moreover, a recent clinical trial showed that targeting of the p40 subunit of IL-12 by neutralizing antibodies suppres…
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Zitierempfehlung
C Becker, H Dornhoff, C Neufert, M Fantini, S Wirtz, S Hübner, A Nikolaev, HA Lehr, AJ Murphy, DM Valenzuela, GD Yancopoulus, PR Galle, M Karow, MF Neurath (2006) IL-23 cross-regulates IL-12 production in T cell dependent experimental colitis. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-2006-950635
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