CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Exonuclease1 (Exo1) deletion rescues crypt atrophy and survival of telomere dysfunctional mice
DOI 10.1055/s-2006-950651
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Autor:innenS Schätzlein, W Edelmann, M Manns, KL Rudolph
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2006
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: The ends of linear chromosomes in yeast and mammalian nuclei are usually maintained either by recombination or telomerase. In the absence of both pathways cells enter senescence due to telomere shortening, which can affect aging and regeneration of tissues in vivo. Exo1, a 5–3 exonuclease, was found to play a decisive role in preventing senescent of budding yeast cells defective for both telomerase- an…
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Zitierempfehlung
S Schätzlein, W Edelmann, M Manns, KL Rudolph (2006) Exonuclease1 (Exo1) deletion rescues crypt atrophy and survival of telomere dysfunctional mice. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-2006-950651
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