CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
p21 deletion rescues stem cell senescence and premature ageing of telomere dysfunctional mice without accelerating cancer formation
DOI 10.1055/s-2006-950673
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Autor:innenA Roy Choudhoury, M Manns, Z Ju, M Djojosubroto, A Stepcynska, H Jiang, A Schienke, A Ganser, P Schirmacher, KL Rudolph
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2006
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: Telomere shortening is associated with acceleration of ageing, chronic disease, and mortality in humans. Mutations that predispose to a failure to maintain telomere length induce a premature decline in organ homeostasis and a shortened lifespan in human and mice. Upon reaching a critically short length, dysfunctional telomeres activate the ATM/p53 DNA damage pathway and its downstream target p21, which…
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Zitierempfehlung
A Roy Choudhoury, M Manns, Z Ju, M Djojosubroto, A Stepcynska, H Jiang, A Schienke, A Ganser, P Schirmacher, KL Rudolph (2006) p21 deletion rescues stem cell senescence and premature ageing of telomere dysfunctional mice without accelerating cancer formation. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-2006-950673
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