CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Carbon monoxide generated from heme degradation suppresses fibrogenic activities of TGF-b1 in primary hepatic stellate cells: involvement of the activation of ERK MAPK pathway
DOI 10.1055/s-2006-950774
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Autor:innenTY Tsui, HJ Schlitt
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2006
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Aims: Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in heme catabolism, which can degrade heme into carbon monoxide (CO), biliverdin and free iron. Previous study have been shown HO-1 can be expressed in activated hepatic stellate cells (HSCs), which might function as a “homeostatic“ molecule in controlling the development of liver fibrosis. However, the mechanism for HO-1 to exert such effects remains largely…
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Zitierempfehlung
TY Tsui, HJ Schlitt (2006) Carbon monoxide generated from heme degradation suppresses fibrogenic activities of TGF-b1 in primary hepatic stellate cells: involvement of the activation of ERK MAPK pathway. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-2006-950774
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