CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
EGFR reactivates telomerase in immortalized squamous epithelial cells through PI3K/AKT-mediated phosphorylation and transcriptional regulation via Hif-1α
DOI 10.1055/s-2006-950878
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Nachweis in CareLit
Autor:innenS Heeg, M Quante, E Scheffer, A von Werder, M Döbele, G Gössel, C Fulda, H Kunert, H Nakagawa, R Beijersbergen, HE Blum, OG Opitz
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: In our cellular model of esophageal carcinogenesis immortalization was induced independent of telomerase but through alternative lengthening of telomeres (ALT). In this stepwise model additional overexpression of EGFR in immortalized cyclin D1 overexpressing/p53 inactivated cells (OKF6 D1/del.p53) led to in vitro transformation and activation of telomerase. This study identifies the cellular pathways i…
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Zitierempfehlung
S Heeg, M Quante, E Scheffer, A von Werder, M Döbele, G Gössel, C Fulda, H Kunert, H Nakagawa, R Beijersbergen, HE Blum, OG Opitz (2006) EGFR reactivates telomerase in immortalized squamous epithelial cells through PI3K/AKT-mediated phosphorylation and transcriptional regulation via Hif-1α. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-2006-950878
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