CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Inhibition of telomerase by mutant template telomerase RNA and anti-telomerase short interfering RNA induces ALT in immortalized human esophageal epithelial cells
DOI 10.1055/s-2006-950885
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Autor:innenM Döbele, A von Werder, C Fulda, S Heeg, G Gössel, M Quante, H Harada, Y Suliman, S Li, EH Blackburn, HE Blum, OG Opitz
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Immortalization is an important step in the malignant transformation of human cells and essentially depends on telomere maintenance. This is either mediated through activation of the enzyme telomerase, which contains a template RNA moiety (hTER) and the core protein (hTERT) or through a recombination based alternative mechanism (ALT). Little is known about the regulation and coexistence of these two me…
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Zitierempfehlung
M Döbele, A von Werder, C Fulda, S Heeg, G Gössel, M Quante, H Harada, Y Suliman, S Li, EH Blackburn, HE Blum, OG Opitz (2006) Inhibition of telomerase by mutant template telomerase RNA and anti-telomerase short interfering RNA induces ALT in immortalized human esophageal epithelial cells. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-2006-950885
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