CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Telomerase limits chromosomal instability and promotes tumor progression at the ‘crisis’ stage of in vivo carcinogenesis
DOI 10.1055/s-2006-950887
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Lechel, H Holstege, Y Begus, A Schienke, A Roy Choudhoury, K Kamino, U Lehmann, H Geerlings, R Geffers, J Buer, MP Manns, S Kubicka, P Schirmacher, J Jonkers, KL Rudolph
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: During early cancer formation most human epithelial cancers transit through a ‘crisis’ stage characterized by profound chromosomal instability associated with telomere dysfunction and loss of p53 checkpoint function. Methods: To analyze the role of telomerase reactivation during carcinogenesis at the crisis stage in vivo we generated a mouse model in which hepatocellular cancer (HCC) was induced by chr…
Zitieren
Zitierempfehlung
A Lechel, H Holstege, Y Begus, A Schienke, A Roy Choudhoury, K Kamino, U Lehmann, H Geerlings, R Geffers, J Buer, MP Manns, S Kubicka, P Schirmacher, J Jonkers, KL Rudolph (2006) Telomerase limits chromosomal instability and promotes tumor progression at the ‘crisis’ stage of in vivo carcinogenesis. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-2006-950887
Mit CareLit weiterarbeiten