CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Resistance development during long-term treatment with Imatinib of patients with recurrent and/or metastatic gastrointestinal stromal tumors – single center experience
DOI 10.1055/s-2006-950954
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Sobotta, T Armbrust, C Langer, H Becker, B Gunawan, L Füzesi, G Ramadori
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: Gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors of the gastrointestinal tract. They are supposed to arise from Cajal cells because of gain-of-function mutations of the tyrosine receptor kinases kit or PDGF-R. The small molecule Imatinib selectively inhibits the kinase activity of both receptors and has been used successfully in the treatment of GIST since 2001. However, increasingly resistan…
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Zitierempfehlung
M Sobotta, T Armbrust, C Langer, H Becker, B Gunawan, L Füzesi, G Ramadori (2006) Resistance development during long-term treatment with Imatinib of patients with recurrent and/or metastatic gastrointestinal stromal tumors – single center experience. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-2006-950954
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