CareLit · DOI-Nachweis · Geburtshilfe und Frauenheilkunde
Lysyl Oxidase is essential for hypoxia-induced metastasis in breast cancer
DOI 10.1055/s-2006-952695
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJT Erler, N Dornhöfer, S Jeffrey, A Giaccia
ZeitschriftGeburtshilfe und Frauenheilkunde
Ausgabe09/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Hypoxic tumor cells are highly aggressive and often metastatic, however the underlying processes remain unclear. Lysyl oxidase (LOX) is an enzyme essential for the formation of the extracellular matrix. We show that LOX expression is regulated by HIF-1 and is associated with hypoxia in human breast tumors. Our data demonstrate that patients with high LOX expressing tumors, have poor distant metastasis-free and overa…
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Zitierempfehlung
JT Erler, N Dornhöfer, S Jeffrey, A Giaccia (2006) Lysyl Oxidase is essential for hypoxia-induced metastasis in breast cancer. Geburtshilfe und Frauenheilkunde (09). https://doi.org/10.1055/s-2006-952695
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