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Fibronectin is elevated in the cerebrospinal fluid of patients with bacterial meningitis and enhances Toll-like receptor induced inflammation in primary mouse microglial cell cultures

M. Lotz, P. Lange, R. Bergmann, S. Ebert, R. Nau · Aktuelle Neurologie · Ausgabe 09/2006

DOI 10.1055/s-2006-952970

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Autor:innenM. Lotz, P. Lange, R. Bergmann, S. Ebert, R. Nau
ZeitschriftAktuelle Neurologie
Ausgabe09/2006
Jahrgang / SeitenNicht angegeben

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Objectives: Toll-like receptors (TLR) play a key role in the recognition of products from virtually all classes of pathogenic organisms. Fibronectin, an extracellular matrix (ECM) protein, is discussed to be a potent stimulator of the innate immune system through Toll-like-receptor 4. In central nervous system (CNS) infections several ECM proteins and bacterial compounds are elevated in the cerebrospinal fluid (CSF)…

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M. Lotz, P. Lange, R. Bergmann, S. Ebert, R. Nau (2006) Fibronectin is elevated in the cerebrospinal fluid of patients with bacterial meningitis and enhances Toll-like receptor induced inflammation in primary mouse microglial cell cultures. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2006-952970

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