CareLit · DOI-Nachweis · Aktuelle Neurologie
Polymorphisms of methionine metabolism and the occurrence of white matter changes in primary central nervous system lymphoma
DOI 10.1055/s-2006-953183
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS. Moskau, M. Linnebank, A. Jurgens, A. Semmler, I.G.H. Schmidt-Wolf, H. Schulz, H. Pels, U. Schlegel
ZeitschriftAktuelle Neurologie
Ausgabe09/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aim: Methotrexate (MTX) is the most efficient cytostatic drug in primary central nervous system lymphoma (PCNSL). It directly interferes with folate and methionine metabolism: MTX inhibits methionine synthesis, which in its active form is an essential substrate for CNS myelination. A typical side effect of treatment with MTX is the occurrence of white matter changes (WMC). We aimed to analyze if polymorphisms influe…
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Zitierempfehlung
S. Moskau, M. Linnebank, A. Jurgens, A. Semmler, I.G.H. Schmidt-Wolf, H. Schulz, H. Pels, U. Schlegel (2006) Polymorphisms of methionine metabolism and the occurrence of white matter changes in primary central nervous system lymphoma. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2006-953183
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