CareLit · DOI-Nachweis · Aktuelle Neurologie
Role of beta-catenin and Wnt-signalling in blood-brain barrier differentiation
DOI 10.1055/s-2006-953486
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Nachweis in CareLit
Autor:innenS. Liebner
ZeitschriftAktuelle Neurologie
Ausgabe09/2006
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and Rational: beta-Catenin is a crucial component of the canonical Wnt pathway in which it acts as a bipartite transcription factor together with LEF/TCF. At adherens junctions of epithelial and endothelial cells (ECs), beta-catenin links the C-terminus of cadherins to the actin cytoskeleton. The conditional inactivation of beta-catenin in ECs leads to embryonic lethality around midgestation because of pl…
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Zitierempfehlung
S. Liebner (2006) Role of beta-catenin and Wnt-signalling in blood-brain barrier differentiation. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2006-953486
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