CareLit · DOI-Nachweis · Pneumologie
Gene therapy of cystic fibrosis by downregulation of ENaC using RNAi
DOI 10.1055/s-2007-1032307
Bibliografische Angaben
Nachweis in CareLit
Autor:innenG Yueksekdag, M Drechsel, C Schmidt, J Rosenecker
ZeitschriftPneumologie
Ausgabe01/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The epithelial Na+ channel (ENaC) seems to play a key role in the pathogenesis of cystic fibrosis lung disease. Its hyperactivation leads to an increased absorption of Na+ by epithelial cells and consecutively to water hyperabsorption, causing an altered airway surface liquid composition (low volume hypothesis). Therefore inhibition of ENaC function in airway epithelia cells could be a promising therapeutic approach…
Zitieren
Zitierempfehlung
G Yueksekdag, M Drechsel, C Schmidt, J Rosenecker (2008) Gene therapy of cystic fibrosis by downregulation of ENaC using RNAi. Pneumologie (01). https://doi.org/10.1055/s-2007-1032307
Mit CareLit weiterarbeiten