Parallel in vitro expansion of human hepatitis C virus specific FoxP3- effector memory and FoxP3+ regulatory CD8+ T cells on recognition of the same antigen

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There is growing consensus that regulatory T cells contribute to regulation of T cell responses to tumors and microbes. FoxP3 has been shown to be the most specific marker for regulatory CD4+ T cells, however, itrsquor;s significance in the CD8+ T cell population is less understood. Here we show that the in vitro stimulation of PBMC from chronically HCV infected patients with specific peptides gives rise to two dist…

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