CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Increased growth and elevated IGF-1 serum concentrations in mice with an adipose tissue specific deletion of the Igf-1 receptor
DOI 10.1055/s-2007-982108
Bibliografische Angaben
Nachweis in CareLit
Autor:innenN Klöting, L Koch, T Wunderlich, M Kern, W Krone, JC Brüning, M Blüher
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe08/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Insulin-like growth factor-1 (IGF-1) and the IGF-1 receptor have been implicated in the regulation of adipocyte differentiation and lipid accumulation in vitro. To investigate the role of IGF-1 receptor in vivo, we created mice with fat-specific disruption of the IGF-1 receptor gene (FIGF-1RKO mice) using the Cre-loxP system. FIGF-1RKO mice have remarkably increased somatic growth most likely as a consequence of ele…
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Zitierempfehlung
N Klöting, L Koch, T Wunderlich, M Kern, W Krone, JC Brüning, M Blüher (2007) Increased growth and elevated IGF-1 serum concentrations in mice with an adipose tissue specific deletion of the Igf-1 receptor. Diabetologie und Stoffwechsel (08). https://doi.org/10.1055/s-2007-982108
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