CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Reduced oxidative stress in hyperglycaemic protein kinase C zeta knock-out mice does not protect against diabetic nephropathy
DOI 10.1055/s-2007-982158
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Meier, JK Park, J Menne, C Lindschau, M Leitges, H Haller
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe08/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Hyperglycemia increases reactive oxygen species (ROS) production e.g. with subsequent activation of the Protein kinase C (PKC) signalling pathway. It has been postulated that a positive feedback loop may occur between ROS and the activation of PKC-ζ as in the diabetic state the PKC-ζ (PKC-ζ) isoform is required for ROS generation from nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in mesangial cells exp…
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Zitierempfehlung
M Meier, JK Park, J Menne, C Lindschau, M Leitges, H Haller (2007) Reduced oxidative stress in hyperglycaemic protein kinase C zeta knock-out mice does not protect against diabetic nephropathy. Diabetologie und Stoffwechsel (08). https://doi.org/10.1055/s-2007-982158
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