CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
RAGE-dependent glyoxalase-1 impairment mediates functional deficits in diabetic neuropathy
DOI 10.1055/s-2007-982194
Bibliografische Angaben
Nachweis in CareLit
Autor:innenSB Stoyanov, I Konrade, GM Haag, IK Lukic, PM Humpert, N Rabbani, P Thornalley, PP Nawroth, A Bierhaus
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe08/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Glycation of proteins, nucleotides and phospholipids contributes to the development of late diabetic complications at least in part via interaction with their cellular receptor RAGE. Reactive intermediates of AGE formation such as glyoxal, methylglyoxal (MG) and other dicarbonyl compounds are detoxified by the glyoxalase-system. Since RAGE-/– mice are partly protected from late diabetic complications i…
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Zitierempfehlung
SB Stoyanov, I Konrade, GM Haag, IK Lukic, PM Humpert, N Rabbani, P Thornalley, PP Nawroth, A Bierhaus (2007) RAGE-dependent glyoxalase-1 impairment mediates functional deficits in diabetic neuropathy. Diabetologie und Stoffwechsel (08). https://doi.org/10.1055/s-2007-982194
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