CareLit · DOI-Nachweis · Aktuelle Neurologie
Localization signals within ataxin-3 influence the formation of intranuclear aggregates in spinocerebellar ataxia type 3
DOI 10.1055/s-2007-987448
Bibliografische Angaben
Nachweis in CareLit
Autor:innenPMA Antony, J Boy, B Henderson, T Stamminger, O Rieß, T Schmidt
ZeitschriftAktuelle Neurologie
Ausgabe09/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Spinocerebellar Ataxia Type 3 (SCA3) or Machado-Joseph disease (MJD), is an autosomal dominantly inherited neurodegenerative disorder caused by the expansion of a CAG stretch in the MJD1 gene resulting in an expanded polyglutamine repeat in the encoded ataxin-3 protein. SCA3 therefore belongs to the group of the so called polyglutamine diseases. Ataxin-3 is mainly localized in the cytoplasm. However, one hallmark of…
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Zitierempfehlung
PMA Antony, J Boy, B Henderson, T Stamminger, O Rieß, T Schmidt (2007) Localization signals within ataxin-3 influence the formation of intranuclear aggregates in spinocerebellar ataxia type 3. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2007-987448
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