CareLit · DOI-Nachweis · Aktuelle Neurologie
Are neurodegerative processes in SCA3 reversible? A study using transgenic mouse models
DOI 10.1055/s-2007-987449
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJ Boy, T Schmidt, U Schumann, J Horst, TB Leergaard, F Odeh, S Nuber, S Beck, C Holzmann, S Ibrahim, U Grasshoff, I Schmitt, F Zimmermann, M Seeliger, S Prusiner, JG Bjaalie, O Rieß
ZeitschriftAktuelle Neurologie
Ausgabe09/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Spinocerebellar Ataxia Type 3 (SCA3) or Machado-Joseph-Disease (MJD) is an autosomal dominantly inherited neurodegenerative disorder caused by the expansion of a CAG stretch in the MJD1 gene encoding a polyglutamine repeat in the respective ataxin-3-protein. In order to study the course of the disease, we generated an inducible transgenic mouse model using the “Tet-Off-System“. This system is based on two constructs…
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Zitierempfehlung
J Boy, T Schmidt, U Schumann, J Horst, TB Leergaard, F Odeh, S Nuber, S Beck, C Holzmann, S Ibrahim, U Grasshoff, I Schmitt, F Zimmermann, M Seeliger, S Prusiner, JG Bjaalie, O Rieß (2007) Are neurodegerative processes in SCA3 reversible? A study using transgenic mouse models. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2007-987449
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