CareLit · DOI-Nachweis · Aktuelle Neurologie
A novel hexameric CD95 ligand as a potent agonist of apoptosis in human glioma cells in vitro and in vivo
DOI 10.1055/s-2007-987569
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Nachweis in CareLit
Autor:innenG Eisele, S Aulwurm, U Naumann, P Roth, M Dupuis, M Weller
ZeitschriftAktuelle Neurologie
Ausgabe09/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Glioblastoma is the most aggressive primary human brain tumor. One feature of the malignant phenotype of gliomas is resistance to CD95-induced apoptosis. CD95/Fas/APO-1 is a member of the tumor necrosis factor (TNF) receptor family. Activation of CD95 leads to caspase-dependent apoptotic cell death in sensitive cells. The soluble form of monomeric CD95 ligand fails to initiate this death cascade but it becomes activ…
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Zitierempfehlung
G Eisele, S Aulwurm, U Naumann, P Roth, M Dupuis, M Weller (2007) A novel hexameric CD95 ligand as a potent agonist of apoptosis in human glioma cells in vitro and in vivo. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2007-987569
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