CareLit · DOI-Nachweis · Aktuelle Neurologie
Beta-Amyloid is a Substrate of Autophagy in Sporadic Inclusion Body Mysositis
DOI 10.1055/s-2007-987613
Bibliografische Angaben
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Autor:innenJ Lunemann, J Schmidt, D Schmid, K Barthel, A Wrede, MC Dalakas, C Munz
ZeitschriftAktuelle Neurologie
Ausgabe09/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Sporadic Inclusion Body Myositis (sIBM) is the most common acquired muscle disease in patients above 50 years of age. Apart from inflammation in the skeletal muscle, overexpression of amyloid precursor protein (APP) and intracellular accumulation of its proteolytic fragment beta-amyloid play a central role in the pathogenesis of sIBM. We demonstrate here that the essential autophagy protein Atg8/LC3, which associate…
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Zitierempfehlung
J Lunemann, J Schmidt, D Schmid, K Barthel, A Wrede, MC Dalakas, C Munz (2007) Beta-Amyloid is a Substrate of Autophagy in Sporadic Inclusion Body Mysositis. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2007-987613
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