CareLit · DOI-Nachweis · Aktuelle Neurologie
Interaction of amyloid precursor protein and beta-secretase on the cell surface
DOI 10.1055/s-2007-987637
Bibliografische Angaben
Nachweis in CareLit
Autor:innenB von Einem, D Schwanzar, M Wagner, P Weber, H Schneckenburger, C von Arnim
ZeitschriftAktuelle Neurologie
Ausgabe09/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Accumulation of amyloid-beta-peptide (Abeta) in senile plaques is a characteristic feature for Alzheimer's disease. The amyloid precursor protein (APP) is cleaved sequentially by beta-site APP-cleaving enzyme (BACE) and gamma-secretase to release Abeta. Recent data indicate that production, clearance, and aggregation of Aß are highly dependent on the specific neuronal subcellular localization wherein Aß is generated…
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Zitierempfehlung
B von Einem, D Schwanzar, M Wagner, P Weber, H Schneckenburger, C von Arnim (2007) Interaction of amyloid precursor protein and beta-secretase on the cell surface. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2007-987637
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