CareLit · DOI-Nachweis · Aktuelle Neurologie
Suppression of kindling epileptogenesis by adenosine-releasing stem cell-derived brain implants
DOI 10.1055/s-2007-987719
Bibliografische Angaben
Nachweis in CareLit
Autor:innenT Li, JA Steinbeck, T Lusardi, P Koch, M Segschneider, JQ Lan, A Wilz, RP Simon, D Boison, O Brüstle
ZeitschriftAktuelle Neurologie
Ausgabe09/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Epilepsy therapy is largely symptomatic and no effective therapy is available to prevent epileptogenesis. We set out to explore the potential of stem cell-derived brain implants to suppress the progressive development of seizures in the rat kindling-model. Embryonic stem (ES) cells, engineered to release the inhibitory neuromodulator adenosine by biallelic genetic disruption of the adenosine kinase gene (Adk-/-), an…
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Zitierempfehlung
T Li, JA Steinbeck, T Lusardi, P Koch, M Segschneider, JQ Lan, A Wilz, RP Simon, D Boison, O Brüstle (2007) Suppression of kindling epileptogenesis by adenosine-releasing stem cell-derived brain implants. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2007-987719
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