CareLit · DOI-Nachweis · Aktuelle Neurologie
Transcriptional effects of conditional parkin-overexpression in PC12-cells
DOI 10.1055/s-2007-987776
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Koch, K Häbig, M Dichgans, T Gasser, M Bonin, CB Lücking
ZeitschriftAktuelle Neurologie
Ausgabe09/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Mutations in the parkin gene are the commonest cause of early-onset, recessive parkinsonism. The parkin protein functions as an E3-ubiquitin-protein ligase. This activity is thought to participate in the detoxification of specific substrate proteins and in intracellular signaling cascades. To further analyse the latter, we have established cell culture conditions using tet-off-PC12 cells, in which parkin can be swit…
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Zitierempfehlung
A Koch, K Häbig, M Dichgans, T Gasser, M Bonin, CB Lücking (2007) Transcriptional effects of conditional parkin-overexpression in PC12-cells. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2007-987776
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