CareLit · DOI-Nachweis · Aktuelle Neurologie
Synphilin-1: generation of conditional knock-out mice
DOI 10.1055/s-2007-987904
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Autor:innenJ Magg, S Bourier, D Vogt-Weisenhorn, R Kühn, W Wurst, A Söhn, O Rieß, T Ott
ZeitschriftAktuelle Neurologie
Ausgabe09/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Synphilin-1 which was identified in yeast two-hybrid screens as an interacting partner of alpha-synuclein is a protein that is involved in the molecular pathogenesis of Parkinson's Disease (PD). Synphilin-1 is found in Lewy bodies in the brains of PD patients and it was shown to promote the formation of intracellular inclusions in cell culture where it co-localizes with alpha-synuclein. Additionally, a R621C mutatio…
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Zitierempfehlung
J Magg, S Bourier, D Vogt-Weisenhorn, R Kühn, W Wurst, A Söhn, O Rieß, T Ott (2007) Synphilin-1: generation of conditional knock-out mice. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2007-987904
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