CareLit · DOI-Nachweis · Aktuelle Neurologie
FRET/FLIM studies on mutant SOD1 detoxification mechanisms in intact single cells
DOI 10.1055/s-2007-987976
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Ganesan, G Rohde, K Sroka, MKE Schaefer, C Dohm, P Kermer, G Haase, F Wouters, M Bähr, JH Weishaupt
ZeitschriftAktuelle Neurologie
Ausgabe09/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Mutant superoxide dismutase 1 (mtSOD1) causes dominantly inherited amyotrophic lateral sclerosis (ALS). The mechanism for mtSOD1 toxicity remains unknown. Two main hypotheses are the impairment of proteasomal function and chaperone depletion by misfolded mtSOD1. Here, we employed FRET/FLIM and biosensor imaging to quantitatively localize ubiquitination as well as chaperone binding of mtSOD1 in single cells, and to a…
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Zitierempfehlung
S Ganesan, G Rohde, K Sroka, MKE Schaefer, C Dohm, P Kermer, G Haase, F Wouters, M Bähr, JH Weishaupt (2007) FRET/FLIM studies on mutant SOD1 detoxification mechanisms in intact single cells. Aktuelle Neurologie (09). https://doi.org/10.1055/s-2007-987976
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