CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
TGF-beta and hepatocyte transdifferentiation in liver fibrogenesis
DOI 10.1055/s-2007-988112
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Autor:innenS Dooley, L Ciuclan, P Godoy, S Kanzler, R Heuchel, E Ueberham, R Gebhardt, J Hamzavi, P Mertens, K Breitkopf
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Chronic liver intoxication results in overrepresentation of TGF-β in the liver, which induces activation of hepatic stellate cells, deposition of extracellular matrix and hepatocyte (HC) apoptosis. Since TGF-β signal transduction and its biological responses are highly complex, we endeavored a Systems Biology approach to understand the diverse observations for TGF-β and Smads in liver cells. Apoptosis assays reveale…
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Zitierempfehlung
S Dooley, L Ciuclan, P Godoy, S Kanzler, R Heuchel, E Ueberham, R Gebhardt, J Hamzavi, P Mertens, K Breitkopf (2007) TGF-beta and hepatocyte transdifferentiation in liver fibrogenesis. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-2007-988112
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