CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Activation of KrasG12D and Tgfa leads to an accelerated carcinogenesis and the develoment of IPMN lesions in a novel endogenous mouse model of pancreatic cancer
DOI 10.1055/s-2007-988130
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Nachweis in CareLit
Autor:innenJT Siveke, H Einwächter, B Sipos, D Saur, G Klöppel, RM Schmid
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Besides activation of an oncogenic KrasG12D mutation, growth factors have been implicated in pancreatic carcinogenesis. In this study we analyzed the effect of pancreas-specific Tgfa overexpression in addition to conditional activation of mutant endogenous KrasG12D. Methods: Elastase-Tgfa mice were crossed to p48+/Cre;Kras+/LSL-G12D mice. Pancreata were analyzed at different time points and after devel…
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Zitierempfehlung
JT Siveke, H Einwächter, B Sipos, D Saur, G Klöppel, RM Schmid (2007) Activation of KrasG12D and Tgfa leads to an accelerated carcinogenesis and the develoment of IPMN lesions in a novel endogenous mouse model of pancreatic cancer. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-2007-988130
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