CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
EGFR-overexpression induces telomerase reactivation and cell cycle progression as distinct steps in a cellular model of oral esophageal carcinogenesis
DOI 10.1055/s-2007-988182
Bibliografische Angaben
Nachweis in CareLit
Autor:innenN Hirt, S Heeg, A Queisser, S Hauß, EM Egenter, H Kunert, M Doebele, M Quante, G Goessel, H Nakagawa, R Beijersbergen, H Blum, O Opitz
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: In our cellular model of oral-esophageal carcinogenesis EGFR-overexpression plays a crucial role in in vitro transformation, telomerase-reactivation and enhanced proliferation of immortalized cyclinD1-overexpressing/p53-inactivated keratinocytes (OKF6-D1/d.n.p53). We previously demonstrated that this is mediated by the activation of the PI3K/AKT-pathway. Our aim was to characterize the cellular mechani…
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Zitierempfehlung
N Hirt, S Heeg, A Queisser, S Hauß, EM Egenter, H Kunert, M Doebele, M Quante, G Goessel, H Nakagawa, R Beijersbergen, H Blum, O Opitz (2007) EGFR-overexpression induces telomerase reactivation and cell cycle progression as distinct steps in a cellular model of oral esophageal carcinogenesis. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-2007-988182
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