CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Severe downregulation of the NHE3 adapterprotein PDZK1 (NHERF3) in colonic mucosa of patients with active IBD – Implications for the dysregulation of salt and water transport
DOI 10.1055/s-2007-988421
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Nachweis in CareLit
Autor:innenK Schröder, B Riederer, O Bachmann, K Franke, H Lenzen, C Meyer, J Wedemeyer, MP Manns, U Seidler
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: Acute flares of UC (ulcerative colitis) an CD (Crohn's disease) are often accompanied by severe diarrhea. A major causative factor is the complete loss of sodium absorptive capacity of the inflamed colonic mucosa of patients with acute UC or CD. Intestinal cell lines incubated with TNFα and IFNγ showed downregulation of the major transport protein for intestinal salt absorption, the Na+/H+ exchanger isoform 3…
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Zitierempfehlung
K Schröder, B Riederer, O Bachmann, K Franke, H Lenzen, C Meyer, J Wedemeyer, MP Manns, U Seidler (2007) Severe downregulation of the NHE3 adapterprotein PDZK1 (NHERF3) in colonic mucosa of patients with active IBD – Implications for the dysregulation of salt and water transport. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-2007-988421
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