CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Bile acid beta glucosidase (GBA2) deficiency leads to glucosylceramide accumulation and modulation of cell signalling in liver
DOI 10.1055/s-2007-988458
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Nachweis in CareLit
Autor:innenY Yildiz, H Matern, S Matern, DW Russell, T Sauerbruch, F Lammert
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2007
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and aims: A novel microsomal bile acid beta glucosidase (GBA2) has been purified and characterized from human liver. GBA2 is evolutionarily highly conserved, ubiquitously present, and hydrolyzes bile acid 3-O-glucosides as endogenous compounds in liver. To gain insight into the biological function of this enzyme and its substrates, we generated mice deficient in GBA2. Methods: Vector construction for Gba2…
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Zitierempfehlung
Y Yildiz, H Matern, S Matern, DW Russell, T Sauerbruch, F Lammert (2007) Bile acid beta glucosidase (GBA2) deficiency leads to glucosylceramide accumulation and modulation of cell signalling in liver. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-2007-988458
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