CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Lipid accumulation in hepatocytes induces activation and pro-fibrotic gene expression in hepatic stellate cells.–A new in vitro model to study fibrogenesis in hepatic steatosis
DOI 10.1055/s-2008-1037459
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Nachweis in CareLit
Autor:innenH Wobser, C Dorn, T Weiss, T Amann, C Bollheimer, R Büttner, J Schölmerich, C Hellerbrand
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Nonalcoholic fatty liver disease (NAFLD) is a frequent and potentially progressive chronic liver disease. A subset of patients with NAFLD develop non-alcoholic steatohepatitis (NASH), hepatic fibrosis and end-stage liver disease. Hepatic stellate cells (HSC) are the central mediators of liver fibrosis. The molecular mechanism linking hepatic steatosis to the activation of HSC, thereby promoting inflammation and fibr…
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Zitierempfehlung
H Wobser, C Dorn, T Weiss, T Amann, C Bollheimer, R Büttner, J Schölmerich, C Hellerbrand (2008) Lipid accumulation in hepatocytes induces activation and pro-fibrotic gene expression in hepatic stellate cells.–A new in vitro model to study fibrogenesis in hepatic steatosis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2008-1037459
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