CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Ammonia increases RNA oxidation in cultured astrocytes and brain in vivo
DOI 10.1055/s-2008-1037460
Bibliografische Angaben
Nachweis in CareLit
Autor:innenB Görg, N Qvartskhava, V Keitel, HJ Bidmon, F Schliess, D Häussinger
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Oxidative stress plays a major role in cerebral ammonia toxicity and the pathogenesis of hepatic encephalopathy (HE) but the mechanisms leading to impaired protein function are still not fully understood. Here we show that ammonia induces a rapid RNA oxidation in cultured rat astrocytes, vital mouse brain slices and rat brain in vivo. Also hypoosmolarity increased RNA oxidation in cultured astrocytes, indicating tha…
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Zitierempfehlung
B Görg, N Qvartskhava, V Keitel, HJ Bidmon, F Schliess, D Häussinger (2008) Ammonia increases RNA oxidation in cultured astrocytes and brain in vivo. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2008-1037460
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