CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Activation of latent TGF-β1 within the hepatocyte contributes to connective tissue growth factor (CTGF/CCN2) expression via entirely intracellular signalling
DOI 10.1055/s-2008-1037476
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Nachweis in CareLit
Autor:innenOA Gressner, B Lahme, K Rehbein, M Siluschek, R Weiskirchen, AM Gressner
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: TGF-β is regarded as the profibrogenic master cytokine. We aimed at analyzing the regulatory link between TGF-b dependent CTGF-induction and intracellular demasking of latent TGF-b in hepatocytes (PC) of healthy and injured livers. Methods: Primary rat PC were cultured in entirely serum- (i.e. TGF-β-) free conditions. Analyses performed included immunoblotting, reporter-assays, metabolic labelling and…
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Zitierempfehlung
OA Gressner, B Lahme, K Rehbein, M Siluschek, R Weiskirchen, AM Gressner (2008) Activation of latent TGF-β1 within the hepatocyte contributes to connective tissue growth factor (CTGF/CCN2) expression via entirely intracellular signalling. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2008-1037476
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