CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Transcriptional activity of Serum Response Factor is mediated by the RhoA/Rho kinase pathway during HSC differentiation and influences expression of Smooth Muscle Cell marker genes
DOI 10.1055/s-2008-1037500
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Autor:innenJ Herrmann, U Haas, AM Gressner, R Weiskirchen
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2008
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Hepatic stellate cells (HSC) are prominent cellular effectors of liver fibrosis, which become activated during liver injury and transdifferentiate from quiescent, fat storing cells into a proliferative myofibroblastic cell type (MFB). This process is accompanied by modulations of gene expression. A common feature of activated HSC is upregulation of genes encoding known markers of smooth muscle cells (SMC), e.g. α-sm…
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Zitierempfehlung
J Herrmann, U Haas, AM Gressner, R Weiskirchen (2008) Transcriptional activity of Serum Response Factor is mediated by the RhoA/Rho kinase pathway during HSC differentiation and influences expression of Smooth Muscle Cell marker genes. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2008-1037500
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