CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Genomic disruption of the Smad7 gene enhances CCl4 dependent liver damage and fibrogenesis in mice
DOI 10.1055/s-2008-1037501
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Autor:innenS Ehnert, P Godoy, J Hamzavi, HL Weng, PR Mertens, S Kanzler, R Heuchel, S Dooley
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
TGF-β signaling is induced as a consequence of liver damage, triggering fibrogenesis in chronic disease. TGF-β effects are blunted by antagonistic Smad7, which is transiently induced upon initiation of TGF-β signaling in most cell types, providing negative feedback regulation, or by IFN-γ, TNF-α or EGF leading to a crosstalk of TGF-β with these pathways. We intoxicated viable S7ΔE1 mice bearing a deleted exon I in t…
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Zitierempfehlung
S Ehnert, P Godoy, J Hamzavi, HL Weng, PR Mertens, S Kanzler, R Heuchel, S Dooley (2008) Genomic disruption of the Smad7 gene enhances CCl4 dependent liver damage and fibrogenesis in mice. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2008-1037501
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