CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Interferon gamma/STAT1 signalling prevents hepatocarcinogenesis by sensitizing for p53-induced apoptosis in response to DNA-damage
DOI 10.1055/s-2008-1037515
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJ Schrader, S Zander, S Lüth, A Lohse, J Herkel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Interferon gamma [IFNgamma] has been implicated in acute and chonic inflammation in the liver. Indeed, IFNgamm-transgenic mice exhibit chronic hepatitis, liver injury and regeneration. Such state of chronic regeneration under inflammatory stress is believed to be a major risk factor for the development of liver cancer. However, we previously found that overexpression of IFN gamma in the liver protected IFNgamma-tran…
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Zitierempfehlung
J Schrader, S Zander, S Lüth, A Lohse, J Herkel (2008) Interferon gamma/STAT1 signalling prevents hepatocarcinogenesis by sensitizing for p53-induced apoptosis in response to DNA-damage. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2008-1037515
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