CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Beta-glucosidase 2 (GBA2) deficiency leads to zonal glucosylceramide accumulation in the liver
DOI 10.1055/s-2008-1037539
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Autor:innenY Yildiz, H Matern, S Matern, S Weber, R Büttner, T Sauerbruch, F Lammert
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and aims: The enzyme beta-glucosidase 2 (GBA2) has been purified and characterized from human liver microsomes. GBA2 is highly conserved and ubiquitously present, and was known to hydrolyze bile acid 3-O-glucosides as endogenous compound in the liver. To gain insight into the pathobiological functions of this enzyme and its substrates, we recently generated Gba2 knockout mice. Methods: Vector construction…
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Zitierempfehlung
Y Yildiz, H Matern, S Matern, S Weber, R Büttner, T Sauerbruch, F Lammert (2008) Beta-glucosidase 2 (GBA2) deficiency leads to zonal glucosylceramide accumulation in the liver. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2008-1037539
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