CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Caspase 8-induced endosomal acidification is an upstream event in CD95-dependent hepatocyte apoptosis
DOI 10.1055/s-2008-1037547
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Autor:innenR Reinehr, S Becker, A Sommerfeld, D Häussinger
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2008
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: In hepatocytes, almost all CD95 receptor is located inside the cell. CD95 ligand was shown to trigger a NADPH oxidase-derived ROS-generation through a ceramide-dependent pathway which finally leads to CD95 trafficking to the plasma membrane [1]. Methods: In hepatocytes from rats and p47phox knock-out mice ceramide formation was detected by HPTLC, ROS-generation by DCFDA- and [Cl-] by MQAE-fluorescence…
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Zitierempfehlung
R Reinehr, S Becker, A Sommerfeld, D Häussinger (2008) Caspase 8-induced endosomal acidification is an upstream event in CD95-dependent hepatocyte apoptosis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2008-1037547
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