CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Sustained oxidative stress (H2O2) increases hepatic iron accumulation via translational stimulation of transferrin receptor 1 synthesis independent of the IRE/IRP network
DOI 10.1055/s-2008-1037551
Bibliografische Angaben
Nachweis in CareLit
Autor:innenB Andriopoulos, S Hegedüsch, J Mangin, J Wang, K Pantopoulos, S Mueller
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: Various inflammatory conditions of the liver are associated with intracellular iron accumulation, e.g. in chronic hepatitis C and alcoholic steatohepatitis which are independent risk factors for disease progression and fibrosis. Previous work showed that the cellular iron master switch iron regulatory protein 1 (IRP1) is rapidly activated when cultured hepatocytes or the whole liver are exposed to H2O2. Howeve…
Zitieren
Zitierempfehlung
B Andriopoulos, S Hegedüsch, J Mangin, J Wang, K Pantopoulos, S Mueller (2008) Sustained oxidative stress (H2O2) increases hepatic iron accumulation via translational stimulation of transferrin receptor 1 synthesis independent of the IRE/IRP network. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2008-1037551
Mit CareLit weiterarbeiten